ZNF350 Gene Summary [Human]
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nuclear body. Part of transcription repressor complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZNF350 |
| Official Name | zinc finger protein 350 [Source:HGNC Symbol;Acc:HGNC:16656] |
| Ensembl ID | ENSG00000256683 |
| Bio databases IDs | |
| Aliases | zinc finger protein 350 |
| Synonyms | ZBRK1, ZFQR, zinc finger protein 350 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZNF350 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- krueppel associated box
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- nucleic acid binding
- Zinc-finger double domain
- zinc finger domain
- protein binding
- KRAB (Kruppel-associated box) domain -A box
- sequence-specific DNA binding
- DNA binding
Pathways
Biological processes and signaling networks where the ZNF350 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- cervical cancer
- metabolic syndrome X
role in cell
- expression in
- growth
- colony formation
- number
- formation
- binding in
- invasion
- transcription in
- repression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- nuclear bodies
- nuclear matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZNF350 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- regulation of transcription, DNA-dependent
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- transcriptional repressor complex
- nuclear matrix
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- metal ion binding
- RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription