SLC5A8 Gene Summary [Human]
SLC5A8 has been shown to transport iodide by a passive mechanism (Rodriguez et al., 2002 [PubMed 12107270]) and monocarboxylates and short-chain fatty acids by a sodium-coupled mechanism (Gopal et al., 2004 [PubMed 15322102]). In kidney, SLC5A8 functions as a high-affinity sodium-coupled lactate transporter involved in reabsorption of lactate and maintenance of blood lactate levels (Thangaraju et al., 2006 [PubMed 16873376]).[supplied by OMIM, Dec 2008]
Details
| Type | Protein Coding |
| Official Symbol | SLC5A8 |
| Official Name | solute carrier family 5 member 8 [Source:HGNC Symbol;Acc:HGNC:19119] |
| Ensembl ID | ENSG00000256870 |
| Bio databases IDs | |
| Aliases | solute carrier family 5 member 8 |
| Synonyms | AIT, RGD1564146, SMCT, SMCT1, solute carrier family 5 (iodide transporter), member 8, solute carrier family 5 member 8 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC5A8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- anion channel
- monocarboxylate porter
- propionate transporter
- sodium ion transporter
- short-chain fatty acid uptake transporter
- protein binding
- monocarboxylic acid transporter
- Solute carrier families 5 and 6-like; solute binding domain
- iodide transporter
- transporter
- organic acid:sodium symporter
- lactate transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- herpes zoster
- head and neck neoplasia
- papillary thyroid carcinoma
- papillary thyroid cancer
- Hurthle cell adenoma
- adenoma formation
- thyroid carcinoma
- epithelial thyroid cancer
- thyroid gland fetal adenoma
role in cell
- expression in
- apoptosis
- colony formation
- uptake in
- inhibition in
- reabsorption in
- mitotic index
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- apical compartment
- apical membrane
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC5A8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- propanoate transport
- nicotinate transport
- chloride transport
- acetate transport
- sodium ion transport
- ion transport
- pyruvate transport
- apoptotic process
- nitrate transport
- lactate transport
- iodide transport
- NAD biosynthesis via nicotinamide riboside salvage pathway
- lactate transmembrane transport
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- GINS complex
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- propionate transmembrane transporter activity
- passive transmembrane transporter activity
- organic acid:sodium symporter activity
- lactate transmembrane transporter activity
- monocarboxylic acid transmembrane transporter activity