DCP1A Gene Summary [Human]
Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Details
| Type | Protein Coding |
| Official Symbol | DCP1A |
| Official Name | decapping mRNA 1A [Source:HGNC Symbol;Acc:HGNC:18714] |
| Ensembl ID | ENSG00000272886 |
| Bio databases IDs | |
| Aliases | decapping mRNA 1A |
| Synonyms | 1110066A22Rik, 4930568L04Rik, D14Ertd817e, decapping mRNA 1A, HSA275986, Mitc1, Nbla00360, RGD1561298, SMAD4IP1, SMIF |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DCP1A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dcp1-like decapping family
- transcription factor binding
- protein binding
- Pleckstrin homology-like domain
- identical protein binding
- kinesin binding
- mRNA-decapping enzyme C-terminus
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- GW body
- cytoplasmic ribonucleoprotein granule
- cytoplasmic mRNA processing body
- Cytoplasm
- cytoplasmic aggregates
- cytosol
- sister chromatids
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DCP1A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- deadenylation-independent decapping of nuclear-transcribed mRNA
- deadenylation-dependent decapping of nuclear-transcribed mRNA
Cellular Component
Where in the cell the gene product is active
- nucleus
- dendrite
- cytoplasm
- membrane
- cytosol
- cytoplasmic mRNA processing body
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- kinesin binding
- mRNA binding
- enzyme activator activity