Gstt1 Gene Summary [Rat]
Enables alkylhalidase activity; glutathione peroxidase activity; and glutathione transferase activity. Involved in several processes, including dichloromethane metabolic process; response to selenium ion; and response to vitamin E. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Biomarker of obesity and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cancer (multiple); cardiovascular system disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human GSTT1 (glutathione S-transferase theta 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gstt1 |
| Official Name | glutathione S-transferase theta 1 [Source:RGD Symbol;Acc:2765] |
| Ensembl ID | ENSRNOG00000049771 |
| Bio databases IDs | |
| Aliases | glutathione S-transferase theta 1 |
| Synonyms | clone 322B1, EC 2.5.1.18, glutathione S-transferase theta 1, glutathione S-transferase, theta 1, Glutathione S-transferase, theta 1, non-human, glutathione S-transferase θ 1, glutathione S-transferase, θ 1, Glutathione S-transferase, θ 1, non-human, GSTT1-1, Gst y1, GSTYRS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gstt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutathione S-transferase, C-terminal domain
- Glutathione S-transferase, N-terminal domain
- C-terminal, alpha helical domain of the Glutathione S-transferase family
- glutathione transferase
- alkylhalidase
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- enzyme
- glutathione peroxidase
- protein binding
Pathways
Biological processes and signaling networks where the Gstt1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- bladder cancer
- cancer
- epithelial cancer
- lung cancer
- skin cancer
- colorectal cancer
- metastatic colorectal cancer
- prostate cancer
- renal cancer
regulates
- glutathione
- ethylene oxide
- methylene chloride
- xenobiotic
- ethylene dibromide
- 1,2-epoxy-3-(p-nitrophenoxy)propane
- cumene hydroperoxide
- 1-bromo-4-nitrobenzene
- epoxide
- 1-chloro-2,4-dinitrobenzene
role in cell
- frequency
- apoptosis
- cytotoxic reaction
- sister chromatid exchange in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- vesicles
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gstt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glutathione metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- glutathione peroxidase activity
- protein binding
- glutathione transferase activity