Gm42742 Gene Summary [Mouse]
Predicted to enable nuclear estrogen receptor binding activity. Involved in DNA damage response; positive regulation of isotype switching to IgG isotypes; and regulation of cell cycle G2/M phase transition. Acts upstream of or within chorion development. Part of histone methyltransferase complex. Is expressed in several structures, including extraembryonic component. Orthologous to human PAGR1 (PAXIP1 associated glutamate rich protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Gm42742 |
| Official Name | predicted gene 42742 [Source:MGI Symbol;Acc:MGI:5662879] |
| Ensembl ID | ENSMUSG00000107068 |
| Bio databases IDs | |
| Aliases | predicted gene 42742 |
| Synonyms | 2900092E17Rik, C16orf53, C77040, GAS, PA1, Pagr1a, PAXIP1 associated glutamate rich protein 1, PAXIP1 associated glutamate rich protein 1A, RGD1305592 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gm42742 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- PAXIP1-associated-protein-1 C term PTIP binding protein
- estrogen receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- growth failure
role in cell
- expression in
- binding in
- apoptosis
- adipogenesis
- cohesion in
- DNA damage response
- cohesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gm42742 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- positive regulation of intracellular estrogen receptor signaling pathway
- DNA recombination
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- histone methyltransferase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- estrogen receptor binding