Traf3ip2 Gene Summary [Mouse]
Enables signaling receptor binding activity and ubiquitin protein ligase activity. Involved in several processes, including cell surface receptor signaling pathway; hematopoietic or lymphoid organ development; and lymphocyte differentiation. Acts upstream of or within B cell apoptotic process and humoral immune response. Is active in cytoplasmic vesicle and nucleus. Used to study Sjogren's syndrome; atopic dermatitis; and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in chronic mucocutaneous candidiasis and psoriasis 13. Orthologous to human TRAF3IP2 (TRAF3 interacting protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Traf3ip2 |
| Official Name | TRAF3 interacting protein 2 [Source:MGI Symbol;Acc:MGI:2143599] |
| Ensembl ID | ENSMUSG00000019842 |
| Bio databases IDs | |
| Aliases | TRAF3 interacting protein 2 |
| Synonyms | ACT1, C6orf2, C6ORF4, C6orf5, C6orf6, CANDF8, CHROMOSOME 6 OPEN READING FRAME 4, CIKS, PSORS13, RGD1304768, TRAF3 interacting protein 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Traf3ip2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- SEFIR domain
- enzyme
- protein binding
- receptor binding
Pathways
Biological processes and signaling networks where the Traf3ip2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lupus-like autoimmune nephritis
- dry eye
- hyperplasia
- impaired glucose tolerance
- xerostomia
- familial candidiasis type 8
- myocardial injury
- psoriasis
- eosinophilia
- neutrophilia
phenotypes
- abnormal cytokine secretion
- abnormal exocrine gland morphology
- abnormal glomerular capillary morphology
- abnormal immune system morphology
- abnormal immune system physiology
- abnormal renal glomerulus morphology
- abnormal spleen B cell corona morphology
- abnormal transitional stage B cell morphology
- blepharitis
- decreased inflammatory response
- decreased interleukin-6 secretion
- decreased susceptibility to autoimmune disorder
- dermatitis
- dry eyes
- enlarged cervical lymph nodes
- enlarged lymph nodes
- enlarged spleen
- enlarged submandibular lymph nodes
- female infertility
- glomerulonephritis
- impaired eosinophil recruitment
- impaired macrophage chemotaxis
- impaired neutrophil recruitment
- increased B cell number
- increased IgE level
- increased IgG level
- increased IgG1 level
- increased IgG2c level
- increased anti-chromatin antibody level
- increased anti-double stranded DNA antibody level
- increased anti-histone antibody level
- increased anti-nuclear antigen antibody level
- increased anti-single stranded DNA antibody level
- increased autoantibody level
- increased dendritic cell number
- increased follicular B cell number
- increased immature B cell number
- increased immunoglobulin level
- increased inflammatory response
- increased marginal zone B cell number
- increased pruritus
- increased spleen weight
- increased submandibular gland size
- increased transitional stage B cell number
- kidney inflammation
- lacrimal gland inflammation
- lymph node hyperplasia
- lymphoid hyperplasia
- mesangial cell hyperplasia
- parotid gland inflammation
- premature death
- renal glomerular immunoglobulin deposits
- respiratory system inflammation
- spleen hyperplasia
- stomatitis
- submandibular gland inflammation
- thick epidermis
- xerostomia
role in cell
- production in
- proliferation
- expression in
- apoptosis
- phosphorylation in
- survival
- activation
- activation in
- differentiation
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Traf3ip2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neutrophil activation
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- signal transduction involved in regulation of gene expression
- spleen development
- lymph node development
- response to xenobiotic stimulus
- skin development
- B cell affinity maturation
- transitional two stage B cell differentiation
- heart development
- inflammatory response
- kidney development
- establishment of T cell polarity
- humoral immune response
- intracellular signal transduction
- positive regulation of defense response to virus by host
- B cell homeostasis
- B cell apoptotic process
- T cell differentiation
- leukocyte activation involved in inflammatory response
- type 2 immune response
- tumor necrosis factor-mediated signaling pathway
- CD40 signaling pathway
- eosinophil mediated immunity
- mucus secretion
- protein import into nucleus
- mRNA stabilization
- protein K63-linked ubiquitination
- T-helper 17 type immune response
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytoplasmic vesicle
- extrinsic to internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor binding