Tnfrsf9 Gene Summary [Mouse]
Enables signaling receptor activity. Acts upstream of or within regulation of immature T cell proliferation in thymus. Predicted to be located in external side of plasma membrane. Is expressed in renal vasculature. Human ortholog(s) of this gene implicated in immunodeficiency 109. Orthologous to human TNFRSF9 (TNF receptor superfamily member 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnfrsf9 |
| Official Name | tumor necrosis factor receptor superfamily, member 9 [Source:MGI Symbol;Acc:MGI:1101059] |
| Ensembl ID | ENSMUSG00000028965 |
| Bio databases IDs | |
| Aliases | tumor necrosis factor receptor superfamily, member 9 |
| Synonyms | 4-1BB, A930040I11RIK, CD137, CDw137, ILA, IMD109, Ly63, TNF receptor superfamily member 9, tumor necrosis factor receptor superfamily, member 9, tumour necrosis factor receptor superfamily, member 9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tnfrsf9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- traf2 binding domain
- laminin homology domain
- signaling receptor activity
- costimulatory domain
- intracellular domain
- TNFR/NGFR cysteine-rich region
- protein binding
- Cys-x-cys-pro motif
- Tumor necrosis factor receptor superfamily (TNFRSF)
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Tnfrsf9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diffuse large B-cell lymphoma
- neoplasia
- atherosclerosis
- proteinuria
- insulin-dependent diabetes mellitus
- high-grade B-cell lymphoma
- cancer
- solid tumor
- breast cancer
- hepatomegaly
role in cell
- growth
- cell death
- expression in
- production in
- apoptosis
- cellular infiltration by
- proliferation
- activation in
- survival
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tnfrsf9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of immature T cell proliferation in thymus
- negative regulation of cell proliferation
- apoptotic process
- regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity