Mest Gene Summary [Mouse]
Predicted to enable hydrolase activity. Involved in regulation of lipid storage and response to retinoic acid. Located in endoplasmic reticulum. Is expressed in several structures, including central nervous system; embryo mesenchyme; extraembryonic component; heart and pericardium; and neural retina. Used to study Barth syndrome. Orthologous to human MEST (mesoderm specific transcript). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mest |
| Official Name | mesoderm specific transcript [Source:MGI Symbol;Acc:MGI:96968] |
| Ensembl ID | ENSMUSG00000051855 |
| Bio databases IDs | |
| Aliases | mesoderm specific transcript |
| Synonyms | mesoderm specific transcript, PEG1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mest often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- epoxide hydrolase
- alpha/beta hydrolase fold
- alpha/beta hydrolases
- Alpha/beta hydrolase family
- Serine aminopeptidase, S33
- peptidase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- small cell lung cancer
- uterine leiomyoma
- leiomyomatosis
- early-onset schizophrenia
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- Ullrich congenital muscular dystrophy
- metastatic colorectal cancer
- endometriosis
role in cell
- apoptosis
- phosphorylation in
- proliferation
- expression in
- migration
- growth
- invasion by
- tubulation by
- enlargement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mest gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mesoderm development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular vesicular exosome
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- hydrolase activity