Vps50 Gene Summary [Mouse]
Predicted to enable SNARE binding activity. Acts upstream of or within endocytic recycling. Predicted to be located in membrane; perinuclear region of cytoplasm; and recycling endosome. Predicted to be part of EARP complex. Orthologous to human VPS50 (VPS50 subunit of EARP/GARPII complex). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vps50 |
| Official Name | VPS50 EARP/GARPII complex subunit [Source:MGI Symbol;Acc:MGI:1920538] |
| Ensembl ID | ENSMUSG00000001376 |
| Bio databases IDs | |
| Aliases | VPS50 EARP/GARPII complex subunit |
| Synonyms | 1700034M03Rik, 8430415E05Rik, BLM, C87205, CCDC132, LOC100911994, mKIAA1861, NEDMSC, RGD1304751, VPS50 EARP/GARPII complex subunit, VPS50 subunit of EARP/GARPII complex, VPS54L |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vps50 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- COG (conserved oligomeric Golgi) complex component, COG2
- Vacuolar-sorting protein 54, of GARP complex
- Protein of unknown function C-terminus (DUF2451)
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- recycling endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vps50 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transport
- retrograde transport, endosome to Golgi
- endocytic recycling
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- membrane
- recycling endosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- SNARE binding