Cmklr1 Gene Summary [Mouse]
Predicted to enable adipokinetic hormone binding activity; adipokinetic hormone receptor activity; and transmembrane signaling receptor activity. Involved in negative regulation of interleukin-12 production; positive regulation of cold-induced thermogenesis; and positive regulation of fat cell differentiation. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; embryo mesenchyme; jaw; lung; and uterus. Orthologous to human CMKLR1 (chemerin chemokine-like receptor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cmklr1 |
| Official Name | chemokine-like receptor 1 [Source:MGI Symbol;Acc:MGI:109603] |
| Ensembl ID | ENSMUSG00000042190 |
| Bio databases IDs | |
| Aliases | chemokine-like receptor 1 |
| Synonyms | chemerin chemokine-like receptor 1, CHEMERINR, ChemR23, DEZ, ERV1, Gpcr27, mcmklr1, RVER1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cmklr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- signaling receptor activity
- chemokine receptor
- G-protein chemoattractant receptor
- 7 transmembrane receptor (rhodopsin family)
- protein-hormone receptor
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- polypeptide hormone binding
Pathways
Biological processes and signaling networks where the Cmklr1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- fibrosis
- diabetes mellitus
- early-onset preeclampsia
- obesity
- Huntington disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- cognitive impairment
- cleft lip
- cerebral amyloid angiopathy
role in cell
- expression in
- phosphorylation in
- quantity
- binding
- migration
- number
- dissemination
- differentiation
- adipogenesis
- chemotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cell periphery
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cmklr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- negative regulation of NF-kappaB transcription factor activity
- positive regulation of fat cell differentiation
- phospholipase C-activating G-protein coupled receptor signaling pathway
- complement receptor mediated signaling pathway
- elevation of cytosolic calcium ion concentration
- chemotaxis
- inflammatory response
- skeletal system development
- immune response
- chemokine-mediated signaling pathway
- positive regulation of macrophage chemotaxis
- regulation of calcium-mediated signaling
- negative regulation of interleukin-12 production
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- complement receptor activity
- G-protein coupled receptor activity
- adipokinetic hormone receptor activity
- protein binding
- adipokinetic hormone binding
- signaling receptor activity
- chemokine receptor activity