Sost Gene Summary [Mouse]
Predicted to enable several functions, including BMP binding activity; DNA-binding transcription factor binding activity; and carbohydrate binding activity. Acts upstream of or within negative regulation of ossification; negative regulation of signal transduction; and ossification. Predicted to be located in Golgi apparatus. Predicted to be part of protein-containing complex. Predicted to be active in extracellular space. Is expressed in several structures, including arterial system; jaw; limb bud; nervous system; and skeleton. Used to study SOST-related sclerosing bone dysplasia and sclerosteosis 1. Human ortholog(s) of this gene implicated in autosomal dominant craniodiaphyseal dysplasia; sclerosteosis; and sclerosteosis 1. Orthologous to human SOST (sclerostin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sost |
| Official Name | sclerostin [Source:MGI Symbol;Acc:MGI:1921749] |
| Ensembl ID | ENSMUSG00000001494 |
| Bio databases IDs | |
| Aliases | sclerostin |
| Synonyms | 5430411E23Rik, CDD, DAND6, SCLEROSTIN, SOST1, VBCH |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sost often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycoprotein hormone beta chain homologues
- transcription factor binding
- protein binding
- carbohydrate binding
- DAN domain
Pathways
Biological processes and signaling networks where the Sost gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- wasting
- osteogenesis imperfecta type I
- osteoporosis
- autosomal dominant craniodiaphyseal dysplasia
- cardiovascular disorder
- postmenopausal osteoporosis
- osteogenesis imperfecta type III
- weight gain
- systemic sclerosis associated interstitial lung disease
role in cell
- expression in
- survival
- apoptosis
- proliferation
- quantity
- number
- differentiation
- abnormal morphology
- mineralization
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi Apparatus
- membrane processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sost gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of BMP signaling pathway
- negative regulation of canonical Wnt receptor signaling pathway
- ossification
- positive regulation of transcription, DNA-dependent
- cellular response to parathyroid hormone stimulus
- BMP signaling pathway
- negative regulation of protein complex assembly
- canonical Wnt receptor signaling pathway
- negative regulation of Wnt receptor signaling pathway
- negative regulation of ossification
- response to mechanical stimulus
Cellular Component
Where in the cell the gene product is active
- extracellular space
- Golgi apparatus
- macromolecular complex
- extracellular region
Molecular Function
What the gene product does at the molecular level
- BMP binding
- protein binding
- heparin binding
- carbohydrate binding