Fkbp10 Gene Summary [Mouse]
Enables FK506 binding activity and peptidyl-prolyl cis-trans isomerase activity. Acts upstream of or within several processes, including aorta morphogenesis; extracellular matrix organization; and protein modification process. Located in endoplasmic reticulum; membrane; and mitochondrial intermembrane space. Is expressed in several structures, including brain vascular element; connective tissue; heart; metanephros; and skeleton. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 11. Orthologous to human FKBP10 (FKBP prolyl isomerase 10). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fkbp10 |
| Official Name | FK506 binding protein 10 [Source:MGI Symbol;Acc:MGI:104769] |
| Ensembl ID | ENSMUSG00000001555 |
| Bio databases IDs | |
| Aliases | FK506 binding protein 10 |
| Synonyms | BRKS, BRKS1, FK506 Binding Protein 10, Fkbp1-rs, Fkbp6, FKBP-65, FKBP prolyl isomerase 10, Fkbprp, Fkbp-rs1, hFKBP65, OI11, OI6, PPIASE, TLH1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fkbp10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FKBP-type peptidyl-prolyl cis-trans isomerase
- peptidylprolyl isomerase
- EF-hand domain pair
- FK506 binding
- EF hand
- EFh
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- organismal death
- Bruck syndrome 1
- osteogenesis imperfecta type III
- metastasis
- osteogenesis imperfecta type XI
- Sengers syndrome
- colorectal cancer
- osteogenesis imperfecta
role in cell
- proliferation
- expression in
- organization
- assembly
- dimerization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum mitochondria contact site
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
- mitochondrial intermembrane space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fkbp10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- wound healing
- aorta morphogenesis
- in utero embryonic development
- extracellular matrix assembly
- collagen fibril organization
- protein folding
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- mitochondrial intermembrane space
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- peptidyl-prolyl cis-trans isomerase activity
- protein binding
- FK506 binding
- calcium ion binding