Hoxc13 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and chromatin binding activity. Acts upstream of or within several processes, including hair follicle development; nail development; and tongue morphogenesis. Located in nucleus. Is expressed in several structures, including integumental system; limb; spinal cord; tail; and tongue. Human ortholog(s) of this gene implicated in ectodermal dysplasia 9. Orthologous to human HOXC13 (homeobox C13). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hoxc13 |
| Official Name | homeobox C13 [Source:MGI Symbol;Acc:MGI:99560] |
| Ensembl ID | ENSMUSG00000001655 |
| Bio databases IDs | |
| Aliases | homeobox C13 |
| Synonyms | ECTD9, homeobox C13, HOX3, HOX3G, N, RGD1563984 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hoxc13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- chromatin binding
- Hox protein A13 N terminal
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- homeodomain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- invasive breast cancer
- lung squamous cell carcinoma
- squamous cell lung cancer
- breast carcinoma
- breast cancer
- renal cancer
- urothelial bladder carcinoma
- alopecia
- endometrial adenocarcinoma
role in cell
- activation in
- expression in
- loss
- differentiation
- transactivation in
- repression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hoxc13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- hair follicle development
- positive regulation of transcription, DNA-dependent
- anterior/posterior pattern specification
- nail development
- anatomical structure morphogenesis
- tongue morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity