Capns1 Gene Summary [Mouse]
Enables calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in protein catabolic process. Predicted to be located in cytosol and membrane. Predicted to be part of calpain complex. Is expressed in medulla oblongata basal plate mantle layer; nucleus pulposus; pons mantle layer; and ventral grey horn. Orthologous to human CAPNS1 (calpain small subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Capns1 |
| Official Name | calpain, small subunit 1 [Source:MGI Symbol;Acc:MGI:88266] |
| Ensembl ID | ENSMUSG00000001794 |
| Bio databases IDs | |
| Aliases | calpain, small subunit 1 |
| Synonyms | CALCIUM-DEPENDENT PROTEASE, SMALL subunit, CALPAIN 30 KDA REGULATORY subunit, CALPAIN4, Calpain Regulatory Subunit, Calpain Small Subunit 1, calpain, small subunit 1, CANP, CANPS, Capa-4, CAPN4, CDPS, Cpns1, CSS1, D7Ertd146e, LOC100912380, PPH6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Capns1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- The penta-EF hand (PEF) family
- binding protein
- calpain
- peptidase
- calcium ion binding
- EFh
- protein binding
Pathways
Biological processes and signaling networks where the Capns1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- primary pulmonary hypertension type 6
- organismal death
- interstitial fibrosis
- bleeding
- heart failure
- myocardial dysfunction
- Huntington disease
role in cell
- cell death
- growth
- accumulation in
- expression in
- differentiation
- apoptosis
- proliferation
- migration
- number
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma membrane fraction
- endoplasmic reticulum fraction
- cellular membrane
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- ER-to-Golgi intermediate compartment
- cytosol
- vesicle fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Capns1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- positive regulation of cell proliferation
- regulation of macroautophagy
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- calcium-dependent cysteine-type endopeptidase activity