Ltbp2 Gene Summary [Mouse]
Predicted to enable microfibril binding activity. Acts upstream of or within supramolecular fiber organization. Located in collagen-containing extracellular matrix. Is expressed in several structures, including cardiovascular system; connective tissue; genitourinary system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in Weill-Marchesani syndrome and megalocornea. Orthologous to human LTBP2 (latent transforming growth factor beta binding protein 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ltbp2 |
| Official Name | latent transforming growth factor beta binding protein 2 [Source:MGI Symbol;Acc:MGI:99502] |
| Ensembl ID | ENSMUSG00000002020 |
| Bio databases IDs | |
| Aliases | latent transforming growth factor beta binding protein 2 |
| Synonyms | C14ORF141, GLC3D, latent transforming growth factor beta binding protein 2, latent transforming growth factor β binding protein 2, MSPKA, MSTP031, WMS3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ltbp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cell-binding domain
- Complement Clr-like EGF-like
- calcium-binding EGF-like domain
- RGD motif
- TB domain
- protein binding
- EGF-like domain
- cysteine rich domain
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- bleomycin-induced pulmonary fibrosis
- idiopathic pulmonary fibrosis
- primary congenital glaucoma type 3D
- exfoliative glaucoma
- androgenic alopecia
- microspherophakia and/or megalocornea with ectopia lentis
- rotator cuff injury
- microspherophakia
- primary open-angle glaucoma
role in cell
- expression in
- phosphorylation in
- differentiation
- migration
- organization
- formation
- quantity
- processing in
- organization in
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ltbp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting
- transforming growth factor beta receptor signaling pathway
- protein secretion
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor binding
- protein binding
- calcium ion binding
- heparin binding
- extracellular matrix structural constituent
- microfibril binding