LTBP2 Gene Summary [Human]
The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | LTBP2 |
| Official Name | latent transforming growth factor beta binding protein 2 [Source:HGNC Symbol;Acc:HGNC:6715] |
| Ensembl ID | ENSG00000119681 |
| Bio databases IDs | |
| Aliases | latent transforming growth factor beta binding protein 2 |
| Synonyms | C14ORF141, GLC3D, latent transforming growth factor beta binding protein 2, latent transforming growth factor β binding protein 2, MSPKA, MSTP031, WMS3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LTBP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cell-binding domain
- Complement Clr-like EGF-like
- calcium-binding EGF-like domain
- RGD motif
- TB domain
- protein binding
- EGF-like domain
- cysteine rich domain
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- bleomycin-induced pulmonary fibrosis
- idiopathic pulmonary fibrosis
- primary congenital glaucoma type 3D
- exfoliative glaucoma
- androgenic alopecia
- microspherophakia and/or megalocornea with ectopia lentis
- rotator cuff injury
- microspherophakia
- primary open-angle glaucoma
role in cell
- expression in
- phosphorylation in
- differentiation
- migration
- organization
- formation
- quantity
- processing in
- organization in
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LTBP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting
- transforming growth factor beta receptor signaling pathway
- protein secretion
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor binding
- protein binding
- calcium ion binding
- heparin binding
- extracellular matrix structural constituent
- microfibril binding