Cd3g Gene Summary [Mouse]
Predicted to enable identical protein binding activity and transmembrane signaling receptor activity. Predicted to be involved in several processes, including positive thymic T cell selection; protein transport; and regulation of lymphocyte apoptotic process. Part of alpha-beta T cell receptor complex. Is expressed in epidermis and lung. Human ortholog(s) of this gene implicated in immunodeficiency 17. Orthologous to human CD3G (CD3 gamma subunit of T-cell receptor complex). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd3g |
| Official Name | CD3 antigen, gamma polypeptide [Source:MGI Symbol;Acc:MGI:88333] |
| Ensembl ID | ENSMUSG00000002033 |
| Bio databases IDs | |
| Aliases | CD3 antigen, gamma polypeptide |
| Synonyms | CD3 antigen, gamma polypeptide, CD3 antigen, γ polypeptide, CD3-GAMMA, CD3 gamma subunit of T-cell receptor complex, Cd3g γ, CD3-γ, CD3 γ subunit of T-cell receptor complex, Ctg-3, IMD17, T3G |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd3g often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- L based internalization motif
- immunoglobulin domain
- protein binding
- identical protein binding
- T-cell surface glycoprotein CD3 delta chain
- sorting signal domain
- dileucine internalization motif
- itam like domain
- cytoplasmic domain
- transmembrane domain
- Immunoreceptor tyrosine-based activation motif
- cytosolic tail domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Cd3g gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Allograft Rejection Signaling
- Antiproliferative Role of TOB in T Cell Signaling
- Autoimmune Thyroid Disease Signaling
- Calcium-induced T Lymphocyte Apoptosis
- CCR5 Signaling in Macrophages
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells
- Dendritic Cell Maturation
- G Protein Signaling Mediated by Tubby
- Glucocorticoid Receptor Signaling
- Graft-versus-Host Disease Signaling
- Lipid Antigen Presentation by CD1
- NF-κB Signaling
- Nur77 Signaling in T Lymphocytes
- OX40 Signaling Pathway
- PKCθ Signaling in T Lymphocytes
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- SAPK/JNK Signaling
- Systemic Lupus Erythematosus Signaling
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- Th17 Activation Pathway
- Th2 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- sepsis
- severe combined immunodeficiency
- metastasis
- B-cell childhood acute lymphoblastic leukemia
- precursor B-cell acute lymphoblastic leukemia
- epithelial cancer
- B-cell acute lymphoblastic lymphoma
- acute lymphoblastic lymphoma
- relapsed B cell acute lymphoblastic leukemia
role in cell
- activation
- expression in
- number
- quantity
- proliferation
- development
- differentiation
- function
- cytolysis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- endocytic vesicle membrane
- cell surface
- cellular membrane
- Nucleus
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cd3g gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gamma-delta T cell activation
- macromolecular complex assembly
- establishment or maintenance of cell polarity
- protein transport
- T cell activation
- adaptive immune response
- cell surface receptor signaling pathway
- alpha-beta T cell activation
- positive thymic T cell selection
- T cell receptor signaling pathway
- regulation of lymphocyte apoptotic process
Cellular Component
Where in the cell the gene product is active
- clathrin-coated endocytic vesicle membrane
- external side of plasma membrane
- cytosol
- plasma membrane
- alpha-beta T cell receptor complex
- gamma-delta T cell receptor complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- transmembrane signaling receptor activity
- protein binding
- T cell receptor binding
- receptor signaling complex scaffold activity