Napsa Gene Summary [Mouse]
Enables endopeptidase activity. Involved in membrane protein proteolysis. Located in alveolar lamellar body and lysosome. Is expressed in several structures, including lung and urinary system. Orthologous to human NAPSA (napsin A aspartic peptidase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Napsa |
| Official Name | napsin A aspartic peptidase [Source:MGI Symbol;Acc:MGI:109365] |
| Ensembl ID | ENSMUSG00000002204 |
| Bio databases IDs | |
| Aliases | napsin A aspartic peptidase |
| Synonyms | Asp 4, Aspartyl protease 4, KAP, Kdap, NAP1, NAPA, NAPSIN, Napsin 1, Napsin A, napsin A aspartic peptidase, pronapsin, SNAPA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Napsa often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Xylanase inhibitor N-terminal
- endopeptidase
- peptidase
- protein binding
- Cellular and retroviral pepsin-like aspartate proteases
- Eukaryotic aspartyl protease
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- epithelial cancer
- epithelial neoplasia
- neoplasia
- lung adenocarcinoma
- lung adenocarcinoma formation
- pleural mesothelioma
- mesothelioma formation
- clear-cell ovarian carcinoma
- clear cell ovarian cancer
role in cell
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
- endosomes
- vesicles
- lysosome
- Endoplasmic Reticulum
- alveolar epithelial lamellar bodies
- multivesicular bodies
- Golgi vesicles
- phagosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Napsa gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane protein proteolysis
- proteolysis
- surfactant homeostasis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- alveolar lamellar body
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- aspartic-type endopeptidase activity
- endopeptidase activity
- peptidase activity