TOP3A Gene Summary [Human]
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | TOP3A |
| Official Name | DNA topoisomerase III alpha [Source:HGNC Symbol;Acc:HGNC:11992] |
| Ensembl ID | ENSG00000177302 |
| Bio databases IDs | |
| Aliases | DNA topoisomerase III alpha, zinc finger, GRF-type containing 7 |
| Synonyms | DNA topoisomerase III alpha, DNA topoisomerase III α, MGRISCE2, PEOB5, TOP3, Top3 alpha, Top3 α, topoisomerase (DNA) III alpha, topoisomerase (DNA) III α, ZGRF7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TOP3A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA topoisomerase type I
- Bacterial DNA topoisomeraes I ATP-binding domain
- Topoisomerase DNA binding C4 zinc finger
- DNA topoisomerase I, archaeal
- TOPRIM
- Toprim domain
- topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins
- GRF zinc finger
- enzyme
- protein binding
- DNA binding
- Bacterial DNA topoisomerase I DNA-binding domain
- DNA topoisomerase
- single-stranded DNA binding
- TOP1Ac
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multiple sclerosis
- hereditary disorder
- uterine leiomyoma
- leiomyomatosis
- microcephaly, growth restriction and increased sister chromatid exchange-2
- mitochondrial disorder
- autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions type 5
role in cell
- expression in
- survival
- growth
- colony formation
- cell viability
- recombination
- formation
- maintenance
- formation in
- maintenance in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Mitochondria
- cytosol
- mitochondrial matrix
- nuclear foci
- chromosome
- nucleoplasm
- nuclear bodies
- PML nuclear bodies
- chromosomal axial elements
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TOP3A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- meiotic cell cycle
- mitochondrial DNA metabolic process
- DNA recombination
- double-strand break repair via homologous recombination
- resolution of recombination intermediates
- DNA topological change
- chromosome separation
Cellular Component
Where in the cell the gene product is active
- nucleus
- PML body
- mitochondrial matrix
- RecQ helicase-Topo III complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- protein binding
- DNA topoisomerase type I activity
- single-stranded DNA binding