Cenps Gene Summary [Mouse]
Predicted to enable DNA binding activity and chromatin binding activity. Predicted to contribute to double-stranded DNA binding activity. Predicted to be involved in DNA repair; replication fork processing; and resolution of meiotic recombination intermediates. Predicted to be located in chromatin. Predicted to be part of FANCM-MHF complex; Fanconi anaemia nuclear complex; and inner kinetochore. Is expressed in brain; sensory organ; skeleton; and testis. Orthologous to several human genes including CENPS (centromere protein S). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Cenps |
| Official Name | centromere protein S [Source:MGI Symbol;Acc:MGI:1917178] |
| Ensembl ID | ENSMUSG00000073705 |
| Bio databases IDs | |
| Aliases | centromere protein S |
| Synonyms | 2610040C18Rik, 2810407L01Rik, APITD1, centromere protein S, FAAP16, MHF1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cenps often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone fold domain (HFD) superfamily
- CENP-S protein
- double-stranded DNA binding
- chromatin binding
- protein binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- kinetochores
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cenps gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- DNA repair
- positive regulation of protein ubiquitination
- resolution of meiotic recombination intermediates
- chromosome segregation
- replication fork processing
- response to DNA damage stimulus
Cellular Component
Where in the cell the gene product is active
- nucleus
- condensed chromosome inner kinetochore
- Fanconi anaemia nuclear complex
- FANCM-MHF complex
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- protein heterodimerization activity
- double-stranded DNA binding
- chromatin binding