Alyref Gene Summary [Mouse]
Enables several functions, including RNA binding activity; RNA folding chaperone; and single-stranded DNA binding activity. Predicted to be involved in mRNA export from nucleus. Predicted to be located in cytoplasm. Predicted to be part of catalytic step 2 spliceosome; exon-exon junction complex; and transcription export complex. Predicted to be active in nucleus. Predicted to colocalize with chromosome, telomeric region. Is expressed in several structures, including branchial arch; central nervous system; future brain; genitourinary system; and sensory organ. Orthologous to human ALYREF (Aly/REF export factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Alyref |
| Official Name | Aly/REF export factor [Source:MGI Symbol;Acc:MGI:1341044] |
| Ensembl ID | ENSMUSG00000025134 |
| Bio databases IDs | |
| Aliases | Aly/REF export factor |
| Synonyms | ALY, ALY/REF, Aly/REF export factor, BEF, LOC688305, REF, REF1, Ref1-I, REF1-II, Refbp1, RNA and export factor binding protein 1, TCRa EBF Interacting Protein 1, Tho4, THOC4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Alyref often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- transcription regulator
- single-stranded DNA binding
- RNA recognition motif
- protein binding activity, bridging
- protein binding
- RNA-binding domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- mammary neoplasm
- head and neck neoplasia
- uterine neoplasm
- stomach neoplasm
- gastrointestinal neoplasia
- lung neoplasm
- colon neoplasm
- colorectal neoplasia
- testicular neoplasm
role in cell
- proliferation
- binding in
- expression in
- colony formation
- survival
- apoptosis
- growth
- cell viability
- autophagy in
- assembly in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- catalytic step 2 spliceosome
- Cytoplasm
- cytosol
- spliceosomes
- nucleoplasm
- nucleoli
- interchromatin granule clusters
- nuclear speckles
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Alyref gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- RNA splicing
- RNA export from nucleus
- osteoblast differentiation
- mRNA processing
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- exon-exon junction complex
- extracellular vesicular exosome
- catalytic step 2 spliceosome
- cytoplasm
- nuclear speck
- membrane
- cytosol
- transcription export complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- mRNA binding