Supt5 Gene Summary [Mouse]
Enables chromatin binding activity. Predicted to be involved in positive regulation of macroautophagy; regulation of DNA-templated transcription; and transcription elongation by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of DSIF complex. Is expressed in several structures, including blastocyst; early embryo; genitourinary system; limb mesenchyme; and nervous system. Orthologous to human SUPT5H (SPT5 homolog, DSIF elongation factor subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Supt5 |
| Official Name | suppressor of Ty 5, DSIF elongation factor subunit [Source:MGI Symbol;Acc:MGI:1202400] |
| Ensembl ID | ENSMUSG00000003435 |
| Bio databases IDs | |
| Aliases | suppressor of Ty 5, DSIF elongation factor subunit |
| Synonyms | SPT5, SPT5H, SPT5 homolog, DSIF elongation factor subunit, suppressor of Ty 5, DSIF elongation factor subunit, Supt5, Tat-CT1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Supt5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPT5 C-terminal repeat
- transcription regulator
- transcription elongation factor Spt5
- KLF1_2_4_N
- C-terminal heptad repeat domain
- enzyme binding
- chromatin binding
- Proline-rich protein
- protein binding
- KOW (Kyprides, Ouzounis, Woese) motif
- 6-pyruvoyl-tetrahydropterin synthase related domain (membrane protein)
- Spt5 C-terminal nonapeptide repeat binding Spt4
- N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- early onset hypertension
- uterine leiomyoma
- leiomyomatosis
role in cell
- differentiation
- expression in
- cell viability
- macroautophagy in
- homologous recombination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Supt5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of macroautophagy
- regulation of transcription elongation from RNA polymerase II promoter
- negative regulation of transcription elongation, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription elongation, DNA-dependent
- transcription elongation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- DSIF complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- protein heterodimerization activity
- mRNA binding
- chromatin binding
- enzyme binding