Dll3 Gene Summary [Mouse]
Predicted to enable Notch binding activity. Involved in skeletal system development. Acts upstream of or within anterior/posterior pattern specification; negative regulation of neurogenesis; and paraxial mesoderm development. Located in plasma membrane. Is expressed in several structures, including blastocyst; central nervous system; future brain; paraxial mesenchyme; and sensory organ. Used to study spondylocostal dysostosis. Human ortholog(s) of this gene implicated in dysostosis and spondylocostal dysostosis 1. Orthologous to human DLL3 (delta like canonical Notch ligand 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dll3 |
| Official Name | delta like canonical Notch ligand 3 [Source:MGI Symbol;Acc:MGI:1096877] |
| Ensembl ID | ENSMUSG00000003436 |
| Bio databases IDs | |
| Aliases | delta like canonical Notch ligand 3 |
| Synonyms | delta like canonical Notch ligand 3, pu, pudgy, SCDO1, δ like canonical Notch ligand 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dll3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- N terminus of Notch ligand C2-like domain
- protein binding
- Delta serrate ligand
- EGF_CA
- notch binding
Pathways
Biological processes and signaling networks where the Dll3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- extensive stage small cell lung cancer
- small cell lung cancer
- colon adenocarcinoma
- spondylocostal dysostosis type 1
- advanced small cell lung cancer
- metastatic small cell lung cancer
- colon epithelial cancer
- recurrent small cell lung cancer
- dysplasia
- autosomal recessive spondylocostal dysostosis
phenotypes
- abnormal axial skeleton morphology
- abnormal bone ossification
- abnormal brain ependyma morphology
- abnormal caudal vertebrae morphology
- abnormal cervical vertebrae morphology
- abnormal cranium morphology
- abnormal dermomyotome development
- abnormal dorsal root ganglion morphology
- abnormal lumbar vertebrae morphology
- abnormal paravertebral ganglion morphology
- abnormal parturition
- abnormal presomitic mesoderm morphology
- abnormal rib morphology
- abnormal rostral-caudal patterning of the somites
- abnormal sclerotome morphology
- abnormal sexual interaction
- abnormal skeleton morphology
- abnormal somite border morphology
- abnormal somite development
- abnormal somite segmentation clock
- abnormal somite shape
- abnormal somite size
- abnormal spinal nerve morphology
- abnormal tail morphology
- abnormal thoracic vertebrae morphology
- abnormal trabecular bone morphology
- abnormal vertebrae development
- abnormal vertebrae morphology
- abnormal vertebral arch morphology
- curly tail
- decreased body length
- decreased caudal vertebrae number
- decreased compact bone thickness
- decreased litter size
- decreased rib number
- decreased vertebrae number
- delayed somite formation
- fused dorsal root ganglion
- hindlimb paralysis
- kinked neural tube
- kinked tail
- kyphosis
- lordosis
- postnatal lethality incomplete penetrance
- rib bifurcation
- rib fusion
- short limbs
- short tail
- short vertebral column
- splayed ribs
- sternebra fusion
- thin tail
- vertebral compression
- vertebral fusion
role in cell
- differentiation
- fate determination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
- Plasma Membrane
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dll3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Notch signaling pathway
- skeletal system development
- somitogenesis
- cell differentiation
- paraxial mesoderm development
- negative regulation of neurogenesis
- compartment pattern specification
- negative regulation of Notch signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium ion binding
- Notch binding