Has1 Gene Summary [Mouse]
Enables hyaluronan synthase activity. Involved in extracellular matrix assembly; hyaluronan biosynthetic process; and polysaccharide biosynthetic process. Located in cytoplasm and membrane. Is active in plasma membrane. Is expressed in several structures, including alimentary system epithelium; face; gonad; heart; and skin. Orthologous to human HAS1 (hyaluronan synthase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Has1 |
| Official Name | hyaluronan synthase 1 [Source:MGI Symbol;Acc:MGI:106590] |
| Ensembl ID | ENSMUSG00000003665 |
| Bio databases IDs | |
| Aliases | hyaluronan synthase 1 |
| Synonyms | HAS, hyaluronan synthase 1, LOC282821, LOC688205 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Has1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyl transferase family group 2
- intracellular loop
- hyaluronan synthase
- enzyme
- protein binding
- Glycosyltransferase like family 2
- identical protein binding
- glycosyltransferase family A
- Glycosyl transferase family 21
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- tumorigenesis
- plasma cell myeloma
- monoclonal gammopathy of undertermined significance
- organismal death
- bladder cancer
- epileptic seizure
role in cell
- morphology
- formation
- expression in
- apoptosis
- transformation
- production in
- activation in
- phosphorylation in
- growth
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- perinuclear region
- cellular membrane
- Golgi Apparatus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Has1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to platelet-derived growth factor stimulus
- glycosaminoglycan biosynthetic process
- extracellular polysaccharide biosynthetic process
- negative regulation of fibroblast migration
- cell adhesion
- extracellular matrix assembly
- hyaluronan biosynthetic process
Cellular Component
Where in the cell the gene product is active
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- hyaluronan synthase activity