Gstm3 Gene Summary [Mouse]
Predicted to enable several functions, including glutathione binding activity; glutathione transferase activity; and protein homodimerization activity. Acts upstream of or within cellular response to xenobiotic stimulus and response to bacterium. Predicted to be located in cytosol and intercellular bridge. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human GSTM1 (glutathione S-transferase mu 1) and GSTM5 (glutathione S-transferase mu 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gstm3 |
| Official Name | glutathione S-transferase, mu 3 [Source:MGI Symbol;Acc:MGI:106026] |
| Ensembl ID | ENSMUSG00000004038 |
| Bio databases IDs | |
| Aliases | glutathione S-transferase, mu 3 |
| Synonyms | Fsc2, Glutathione S-Transferase5, glutathione S-transferase mu 3, glutathione S-transferase, mu 3, Glutathione S-transferase, mu 3l, Gst Gt9.3, Gstm3l, Gstm3l1, Gstm4, GstYb4, Gt9.3, mGSTM5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gstm3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutathione S-transferase, C-terminal domain
- Glutathione S-transferase, N-terminal domain
- C-terminal, alpha helical domain of the Glutathione S-transferase family
- binding protein
- glutathione transferase
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- enzyme binding
- protein homodimerization
- enzyme
Pathways
Biological processes and signaling networks where the Gstm3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- glutathione
- 1-chloro-2,4-dinitrobenzene
- trans-4-phenylbut-3-en-2-one
- cumene hydroperoxide
- ethacrynic acid
- 3,4-dichloronitrobenzene
- sulfobromophthalein
- p-nitrophenyl acetate
- 4-nitrobenzyl chloride
- 1,2-epoxy-3-(p-nitrophenoxy)propane
role in cell
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic bridges
- cytosol