Spz1 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including genitourinary system and heart. Orthologous to human SPZ1 (spermatogenic leucine zipper 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spz1 |
| Official Name | spermatogenic leucine zipper 1 [Source:MGI Symbol;Acc:MGI:1930801] |
| Ensembl ID | ENSMUSG00000046957 |
| Bio databases IDs | |
| Aliases | spermatogenic leucine zipper 1 |
| Synonyms | 1700027M20Rik, CILD38, NYD-TSP1, PPP1R148, spermatogenic leucine zipper 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spz1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- liver cancer
- organismal death
- hepatocellular carcinoma
- neoplastic cell transformation
role in cell
- expression in
- proliferation
- transactivation in
- migration
- cell cycle progression
- colony formation
- invasion by
- binding in
- interaction in
- dissemination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spz1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding