Ndrg2 Gene Summary [Mouse]
Acts upstream of or within negative regulation of ERK1 and ERK2 cascade; negative regulation of vascular associated smooth muscle cell proliferation; and regulation of cytokine production. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; musculoskeletal system; and sensory organ. Orthologous to human NDRG2 (NDRG family member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ndrg2 |
| Official Name | N-myc downstream regulated gene 2 [Source:MGI Symbol;Acc:MGI:1352498] |
| Ensembl ID | ENSMUSG00000004558 |
| Bio databases IDs | |
| Aliases | N-myc downstream regulated gene 2 |
| Synonyms | NDR2, Ndrg2b1, NDRG family member 2, N-myc downstream regulated gene 2, SYLD |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ndrg2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha/beta hydrolases
- Ndr family
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- diabetic nephropathy
- papillomatosis
- neoplasia
- psoriasis
- breast cancer
- metastasis
- liver cancer
role in cell
- expression in
- differentiation
- phosphorylation in
- activation in
- proliferation
- apoptosis
- growth
- migration
- survival
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- Golgi Apparatus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ndrg2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- negative regulation of ERK1 and ERK2 cascade
- cell differentiation
- Wnt receptor signaling pathway
- regulation of platelet-derived growth factor production
- regulation of vascular endothelial growth factor production
- negative regulation of cytokine production
- substantia nigra development
Cellular Component
Where in the cell the gene product is active
- growth cone
- nucleus
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein binding