Myo9b Gene Summary [Mouse]
Enables GTPase activator activity and microfilament motor activity. Acts upstream of or within several processes, including Rho protein signal transduction; lamellipodium morphogenesis; and leukocyte chemotaxis. Located in filopodium tip and lamellipodium. Is expressed in several structures, including brain; heart; sensory organ; and skeletal muscle. Orthologous to human MYO9B (myosin IXB). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myo9b |
| Official Name | myosin IXb [Source:MGI Symbol;Acc:MGI:106624] |
| Ensembl ID | ENSMUSG00000004677 |
| Bio databases IDs | |
| Aliases | myosin IXb |
| Synonyms | CELIAC4, FLJ11339, Myosin IXB, MYR5, Unconventional myosin 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myo9b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- IQ (isoleucine-glutamine) motif containing G and D (IQCG and IQCD)
- ADP binding
- ATP binding
- microfilament motor protein
- GTPase activator
- enzyme
- GTPase Activating Protein domain
- RhoGAP
- GTPase-activator protein for Rho-like GTPases
- ATPase
- proline rich domain
- Calmodulin-binding motif
- zinc ion binding
- actin binding
- protein kinase C conserved region 1 (C1 domain) superfamily
- ATP-dependent protein binding
- tail domain
- calmodulin binding
- Myosin and Kinesin motor domain
- enzyme binding
- protein binding
- receptor binding
- acidic domain
- Myosin head (motor domain)
- IQ calmodulin-binding motif
- actin filament binding
- Ubl1_cv_Nsp3_N-like
- zinc finger domain
- motor protein
- Myosin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- epithelial cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- colorectal cancer
- respiratory disorder
- coronary artery disease
- gastric ulcer
- prostatic carcinoma
- prostate cancer
role in cell
- expression in
- proliferation
- recruitment
- polarization
- number
- motility
- migration
- cell spreading
- invasion by
- phagocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ruffle
- cytoskeleton
- perinuclear region
- actin cytoskeleton
- cell cortex
- actin filaments
- cytosol
- filopodia
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Myo9b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Roundabout signaling pathway
- regulation of Rho protein signal transduction
- regulation of small GTPase mediated signal transduction
- ARF protein signal transduction
- lamellipodium morphogenesis
- Rho protein signal transduction
- actin filament-based movement
Cellular Component
Where in the cell the gene product is active
- myosin complex
- perinuclear region of cytoplasm
- cytoplasm
- cell cortex
- membrane
- actin cytoskeleton
- ruffle
- cytosol
- actin filament
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- protein homodimerization activity
- GTPase activator activity
- ADP binding
- microfilament motor activity
- actin filament binding
- ATP binding
- Roundabout binding
- calmodulin binding
- protein binding
- actin binding
- metal ion binding
- small GTPase binding