Tbl2 Gene Summary [Mouse]
Predicted to enable phosphoprotein binding activity; protein kinase binding activity; and translation initiation factor binding activity. Predicted to be involved in cellular response to glucose starvation; cellular response to hypoxia; and endoplasmic reticulum unfolded protein response. Predicted to be active in endoplasmic reticulum. Orthologous to human TBL2 (transducin beta like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tbl2 |
| Official Name | transducin (beta)-like 2 [Source:MGI Symbol;Acc:MGI:1351652] |
| Ensembl ID | ENSMUSG00000005374 |
| Bio databases IDs | |
| Aliases | transducin (beta)-like 2 |
| Synonyms | C76179, transducin (beta)-like 2, transducin beta like 2, transducin (β)-like 2, transducin β like 2, WBSCR13, WS-betaTRP, WS-bTRP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tbl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- WD40 repeats
- WD domain, G-beta repeat
- phosphoprotein binding
- WD40
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- endoplasmic reticulum mitochondria contact site
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tbl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endoplasmic reticulum unfolded protein response
- cellular response to hypoxia
- cellular response to glucose starvation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- RNA binding
- phosphoprotein binding
- translation initiation factor binding