Nde1 Gene Summary [Mouse]
Enables identical protein binding activity and microtubule binding activity. Involved in centrosome duplication and neuron migration. Acts upstream of or within microtubule nucleation; nervous system development; and vesicle transport along microtubule. Located in spindle pole centrosome and synapse. Is expressed in several structures, including brain; cardiovascular system; liver; musculature; and spleen. Human ortholog(s) of this gene implicated in lissencephaly 4. Orthologous to human NDE1 (nudE neurodevelopment protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nde1 |
| Official Name | nudE neurodevelopment protein 1 [Source:MGI Symbol;Acc:MGI:1914453] |
| Ensembl ID | ENSMUSG00000022678 |
| Bio databases IDs | |
| Aliases | nudE neurodevelopment protein 1 |
| Synonyms | 2810027M15Rik, HOM-TES-87, LIS4, LOC103690118, MHAC, mNudE, NDE, NUDE, NUDE1, nudE neurodevelopment protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nde1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- cGMP-dependent protein kinase interacting domain
- TPR/MLP1/MLP2-like protein
- Tropomyosin like
- NUDE protein, C-terminal conserved region
- coiled-coil domain
- protein domain specific binding
- protein binding
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- LIS1 binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- organismal death
- aldosterone producing adrenocortical adenoma
- lissencephaly type 4
- anaplastic thyroid carcinoma
- anaplastic thyroid cancer
- epithelial thyroid cancer
- hyperplasia
- microhydranencephaly
- stuttering
role in cell
- quantity
- proliferation
- differentiation
- migration
- organization
- mitosis
- number
- assembly
- duplication
- nucleation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- perinuclear body
- spindle apparatus
- Cytoplasm
- perinuclear region
- cell cortex
- centrosome
- intercellular junctions
- microtubule organizing centers
- cytosol
- basolateral cell surfaces
- synapse
- mitotic spindle
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nde1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- microtubule nucleation
- chromosome segregation
- mitotic centrosome separation
- cerebral cortex development
- centrosome localization
- cell division
- establishment of mitotic spindle orientation
- neuron migration
- neuroblast proliferation
- centrosome duplication
- vesicle transport along microtubule
- cell migration
- establishment of chromosome localization
Cellular Component
Where in the cell the gene product is active
- spindle pole centrosome
- centrosome
- cleavage furrow
- membrane
- cytosol
- kinesin complex
- kinetochore
- synapse
- microtubule
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- microtubule binding