Fzd8

Enables several functions, including PDZ domain binding activity; Wnt receptor activity; and Wnt-protein binding activity. Involved in Wnt signaling pathway. Acts upstream of or within several processes, including T cell differentiation in thymus; canonical Wnt signaling pathway; and positive regulation of JUN kinase activity. Located in plasma membrane. Part of Wnt-Frizzled-LRP5/6 complex. Is active in neuronal dense core vesicle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human FZD8 (frizzled class receptor 8). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fzd8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Fzd8 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Fzd8 gene, providing context for its role in the cell.