Neurl1a Gene Summary [Mouse]
Enables translation factor activity, non-nucleic acid binding and ubiquitin protein ligase activity. Involved in several processes, including positive regulation of filopodium assembly; positive regulation of long-term neuronal synaptic plasticity; and regulation of synapse organization. Acts upstream of or within lactation; positive regulation of epidermal growth factor-activated receptor activity; and sperm axoneme assembly. Located in several cellular components, including dendrite; perikaryon; and plasma membrane. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including limb; limb bud; nervous system; sensory organ; and skin. Orthologous to human NEURL1 (neuralized E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Neurl1a |
| Official Name | neuralized E3 ubiquitin protein ligase 1A [Source:MGI Symbol;Acc:MGI:1334263] |
| Ensembl ID | ENSMUSG00000006435 |
| Bio databases IDs | |
| Aliases | neuralized E3 ubiquitin protein ligase 1A |
| Synonyms | 2410129E16Rik, bA416N2.1, neu, Neu1, NEUR1, neuralized E3 ubiquitin protein ligase 1, neuralized E3 ubiquitin protein ligase 1A, NEURL, Neurl1a, Nlz, RNF67 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Neurl1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPRY domain
- ubiquitin protein ligase activity
- neuralized homology repeat
- enzyme
- Ring finger domain
- protein binding
- non-nucleic acid binding translation factor
- domain in neuralized proteins
- translation regulator
- Neuralized
- myristoylation sequence
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon cancer
- atrial fibrillation
- schizophrenia
- major depression
- cardioembolic stroke
- arrhythmia
- atrial flutter
- pervasive developmental disorder
- attention deficit hyperactivity disorder
- bipolar disorder
regulated by
- cocaine
- SMYD3
- Caco2 cells
role in cell
- proliferation
- apoptosis
- quantity
- growth
- assembly
- motility
- plasticity
- development
- movement
- cell movement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- perinuclear region
- Plasma Membrane
- dendritic spines
- perikaryon
- postsynaptic density
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Neurl1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of synapse maturation
- negative regulation of cell proliferation
- nervous system development
- positive regulation of filopodium assembly
- positive regulation of dendritic spine development
- lactation
- sperm axoneme assembly
- negative regulation of Notch signaling pathway
- protein monoubiquitination
- regulation of translation
- cellular response to amino acid stimulus
- Notch signaling pathway
- skeletal muscle tissue development
- positive regulation of apoptotic process
- positive regulation of long-term neuronal synaptic plasticity
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- perinuclear region of cytoplasm
- dendritic spine
- perikaryon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- translation factor activity, non-nucleic acid binding
- protein binding
- metal ion binding