Smyd3 Gene Summary [Mouse]
Enables RNA polymerase II complex binding activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and histone H3K36 dimethyltransferase activity. Acts upstream of or within several processes, including cellular response to dexamethasone stimulus; nucleosome assembly; and regulation of protein phosphorylation. Located in nucleus. Is expressed in several structures, including cerebral cortex; early conceptus; gonad; hemolymphoid system gland; and liver. Orthologous to human SMYD3 (SET and MYND domain containing 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Smyd3 |
| Official Name | SET and MYND domain containing 3 [Source:MGI Symbol;Acc:MGI:1916976] |
| Ensembl ID | ENSMUSG00000055067 |
| Bio databases IDs | |
| Aliases | SET and MYND domain containing 3 |
| Synonyms | 2410008A19Rik, bA74P14.1, KMT3E, LOC107985597, LOC107985726, LOC112268277, SET and MYND domain containing 3, ZMYND1, ZNFN3A1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Smyd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone methyltransferase
- MYND finger
- double-stranded DNA binding
- histone lysine N-methyltransferase activity (H3-K36 specific)
- nucleic acid binding
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
- enzyme binding
- enzyme
- protein binding
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- liver cancer
- migraines
- idiopathic scoliosis
- hepatitis B virus-related hepatocellular carcinoma
- hepatocellular carcinoma
- tumorigenesis
- strabismus
- organismal death
role in cell
- growth
- expression in
- phosphorylation in
- transcription in
- proliferation
- invasion by
- assembly
- tumorsphere formation by
- colony formation by
- tumorigenicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Smyd3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- establishment of protein localization
- myotube cell development
- positive regulation of transcription from RNA polymerase II promoter
- cellular response to dexamethasone stimulus
- nucleosome assembly
- methylation
- positive regulation of peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II core binding