Cks1b Gene Summary [Mouse]
Predicted to enable several functions, including cyclin-dependent protein serine/threonine kinase activator activity; histone binding activity; and ubiquitin binding activity. Acts upstream of or within fibroblast proliferation; mitotic cell cycle phase transition; and regulation of DNA-templated transcription. Predicted to be part of SCF ubiquitin ligase complex and cyclin-dependent protein kinase holoenzyme complex. Is expressed in several structures, including 1st branchial arch; cerebral cortex; limb; and neural retina. Orthologous to human CKS1B (CDC28 protein kinase regulatory subunit 1B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cks1b |
| Official Name | CDC28 protein kinase 1b [Source:MGI Symbol;Acc:MGI:1889208] |
| Ensembl ID | ENSMUSG00000028044 |
| Bio databases IDs | |
| Aliases | CDC28 protein kinase 1b |
| Synonyms | 2410005G18Rik, 2610005D03Rik, CDC28 protein kinase 1b, CDC28 protein kinase regulatory subunit 1B, CDC28 REGULATORY subunit 1B, CKS1, ckshs1, PNAS-16, PNAS-18, RGD1561797, sid1334, Sid1334p, Suc1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cks1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- anion binding exosite
- protein binding
- enzyme
- cyclin-dependent kinase binding domain
- Cyclin-dependent kinase regulatory subunit
Pathways
Biological processes and signaling networks where the Cks1b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic myeloid leukemia
- cancer
- neoplasia
- squamous cell cancer
- epithelial cancer
- epithelial neoplasia
- lung adenocarcinoma
- lung adenocarcinoma formation
- hepatocellular carcinoma
- liver cancer
role in cell
- expression in
- growth
- transcription in
- proliferation
- activation in
- cell viability
- apoptosis
- senescence
- colony formation
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cks1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fibroblast proliferation
- cell division
- regulation of transcription, DNA-dependent
- regulation of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- cyclin-dependent protein kinase holoenzyme complex
- SCF ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- ubiquitin binding
- histone binding