Mc5r Gene Summary [Mouse]
Predicted to enable hormone binding activity and melanocortin receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to be active in cytoplasm and plasma membrane. Is expressed in skin. Orthologous to human MC5R (melanocortin 5 receptor). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mc5r |
| Official Name | melanocortin 5 receptor [Source:MGI Symbol;Acc:MGI:99420] |
| Ensembl ID | ENSMUSG00000007480 |
| Bio databases IDs | |
| Aliases | melanocortin 5 receptor |
| Synonyms | MC2, melanocortin 5 receptor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mc5r often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- melanocortin receptor
- hormone binding
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Mc5r gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- interstitial fibrosis
- reduced libido
- acquired generalized hypoactive sexual desire disorder
- perivascular fibrosis
role in cell
- expression in
- phosphorylation in
- accumulation in
- incorporation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mc5r gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- regulation of metabolic process
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- melanocortin receptor activity
- protein binding
- hormone binding