Syf2 Gene Summary [Mouse]
Acts upstream of or within several processes, including gastrulation; in utero embryonic development; and mitotic G2 DNA damage checkpoint signaling. Located in nucleus. Is expressed in cerebral cortex ventricular layer; cortical plate; and embryo. Orthologous to human SYF2 (SYF2 pre-mRNA splicing factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Syf2 |
| Official Name | SYF2 homolog, RNA splicing factor (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1915842] |
| Ensembl ID | ENSMUSG00000028821 |
| Bio databases IDs | |
| Aliases | SYF2 homolog, RNA splicing factor (S. cerevisiae) |
| Synonyms | 1110018L13Rik, CBPIN, D4Bwg1551e, fSAP29, Gcipip, mp29, NTC31, P29, SYF2 homolog, RNA splicing factor (S. cerevisiae), SYF2 pre-mRNA-splicing factor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Syf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- SYF2 splicing factor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- catalytic step 2 spliceosome
- Cytoplasm
- spliceosomes
- nucleoplasm
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Syf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle G2/M transition DNA damage checkpoint
- in utero embryonic development
- positive regulation of cell proliferation
- embryonic organ development
- gastrulation
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- catalytic step 2 spliceosome
- post-mRNA release spliceosomal complex
- nuclear speck
- U2-type catalytic step 2 spliceosome
- Prp19 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding