Ptpro Gene Summary [Mouse]
Enables Wnt-protein binding activity; protein homodimerization activity; and protein tyrosine phosphatase activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity; and plasma membrane bounded cell projection organization. Located in apical plasma membrane; dendritic spine; and lateral plasma membrane. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic density membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and spinal cord. Human ortholog(s) of this gene implicated in nephrotic syndrome type 6. Orthologous to human PTPRO (protein tyrosine phosphatase receptor type O). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Ptpro |
| Official Name | protein tyrosine phosphatase, receptor type, O [Source:MGI Symbol;Acc:MGI:1097152] |
| Ensembl ID | ENSMUSG00000030223 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase, receptor type, O |
| Synonyms | D28, GLEPP, GLEPP1, NPHS6, protein tyrosine phosphatase receptor type O, protein tyrosine phosphatase, receptor type, O, PTPBK, PTPN15, PTP-OC, PTP PHI, PTPROT, PTP-U2, PTP-ο, RPTP-BK, R-PTP-O |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptpro often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wnt-protein binding
- protein-tyrosine-phoshatase
- catalytic domain
- Protein tyrosine phosphatase, catalytic domain
- Fibronectin type 3 domain
- PTP_DSP_cys
- protein binding
- Protein tyrosine phosphatase, catalytic domain motif
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- Protein-tyrosine phosphatase
- FN3
- phosphatase
- protein homodimerization
- intracellular domain
- cadherin binding
Pathways
Biological processes and signaling networks where the Ptpro gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- gastroesophageal reflux
- neutropenia
- antiphospholipid syndrome
- androgenic alopecia
- coronary artery disease
- metastasis
- diabetic nephropathy
- lung adenocarcinoma
- lung adenocarcinoma formation
role in cell
- expression in
- phosphorylation in
- proliferation
- apoptosis
- differentiation
- survival
- assembly
- colony formation
- quantity
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- membrane ruffles
- apical membrane
- synaptic membrane
- lateral plasma membrane
- dendritic spines
- growth cone
- neurites
- synapse
- axons
- podocyte slit diaphragm
- glomerular basement membrane
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptpro gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of synapse organization
- regulation of glomerular filtration
- cell morphogenesis
- protein dephosphorylation
- slit diaphragm assembly
- axon guidance
- negative regulation of retinal ganglion cell axon guidance
- negative regulation of canonical Wnt receptor signaling pathway
- negative regulation of glomerular filtration
- glomerulus development
- negative regulation of cell-substrate adhesion
- negative regulation of neuron projection development
- monocyte chemotaxis
- glomerular visceral epithelial cell differentiation
- lamellipodium assembly
- peptidyl-tyrosine dephosphorylation
Cellular Component
Where in the cell the gene product is active
- growth cone
- lateral plasma membrane
- extracellular vesicular exosome
- dendritic spine
- membrane
- neuron projection
- plasma membrane
- axon
- apical plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding
- protein tyrosine phosphatase activity
- cadherin binding
- phosphatase activity
- transmembrane receptor protein tyrosine phosphatase activity
- Wnt-protein binding