BCL2L13 Gene Summary [Human]
This gene encodes a mitochondrially-localized protein with conserved B-cell lymphoma 2 homology motifs. Overexpression of the encoded protein results in apoptosis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
Details
| Type | Processed Transcript |
| Official Symbol | BCL2L13 |
| Official Name | BCL2 like 13 [Source:HGNC Symbol;Acc:HGNC:17164] |
| Ensembl ID | ENSG00000099968 |
| Bio databases IDs | |
| Aliases | BCL2 like 13 |
| Synonyms | BCL2 like 13, BCL-RAMBO, E430016C20Rik, MIL1, ZD77D08 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BCL2L13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Bcl-2_like
- Bcl-2 homology 1 domain
- membrane-association domain
- Bcl-2 homology 2 domain
- Bcl-2 homology 3 domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- acute myeloid leukemia
- glioblastoma cancer
- glioma cancer
- glioma formation
- central nervous system cancer
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- CD30 positive anaplastic large cell lymphoma
- glioblastoma
role in cell
- differentiation
- organization
- apoptosis
- activation in
- mitochondrial membrane permeabilization
- mitochondrial membrane permeabilization in
- glycolysis in
- mitophagy in
- homodimerization in
- oxidative phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BCL2L13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic process
- regulation of apoptotic process
- activation of cysteine-type endopeptidase activity involved in apoptotic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial membrane
- membrane
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- protein binding
- cysteine-type endopeptidase activator activity involved in apoptotic process