Impdh2 Gene Summary [Mouse]
Enables IMP dehydrogenase activity. Involved in 'de novo' XMP biosynthetic process and GMP biosynthetic process. Acts upstream of or within cellular response to interleukin-4; lymphocyte proliferation; and purine nucleotide biosynthetic process. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; heart; respiratory system; and sensory organ. Orthologous to human IMPDH2 (inosine monophosphate dehydrogenase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Impdh2 |
| Official Name | inosine monophosphate dehydrogenase 2 [Source:MGI Symbol;Acc:MGI:109367] |
| Ensembl ID | ENSMUSG00000062867 |
| Bio databases IDs | |
| Aliases | inosine monophosphate dehydrogenase 2 |
| Synonyms | IMPD, IMPD 2, Imp dehydrogenase 2, Impdh, IMPDH-II, inosine 5'-phosphate dehydrogenase 2, inosine monophosphate dehydrogenase 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Impdh2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CBS_pair_SF
- nucleotide binding
- Domain in cystathionine beta-synthase and other proteins
- IMP dehydrogenase
- TIM-like beta/alpha barrel domains
- CBS domain
- IMP dehydrogenase / GMP reductase domain
- enzyme
- protein binding
- identical protein binding
- inosine-5'-monophosphate dehydrogenase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- HIV infection
- cancer
- infection
- insulin-dependent diabetes mellitus
- heart disease
- neoplasia
- chronic renal failure
- chronic kidney disease
- hepatic steatosis
- end stage renal disease
role in cell
- function
- production in
- activation
- expression in
- proliferation
- apoptosis
- phosphorylation in
- differentiation
- abnormal morphology
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Impdh2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lymphocyte proliferation
- GTP biosynthetic process
- cellular response to interleukin-4
- GMP biosynthetic process
- circadian rhythm
- 'de novo' XMP biosynthetic process
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- nucleus
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
- secretory granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- DNA binding
- RNA binding
- protein binding
- metal ion binding
- IMP dehydrogenase activity