Muc5ac Gene Summary [Mouse]
Acts upstream of or within maintenance of lens transparency. Located in extracellular space. Is expressed in male reproductive gland or organ; nasal cavity epithelium; respiratory system; and stomach. Used to study dry eye syndrome. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease and dry eye syndrome. Orthologous to human MUC5AC (mucin 5AC, oligomeric mucus/gel-forming). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Muc5ac |
| Official Name | mucin 5, subtypes A and C, tracheobronchial/gastric [Source:MGI Symbol;Acc:MGI:104697] |
| Ensembl ID | ENSMUSG00000037974 |
| Bio databases IDs | |
| Aliases | mucin 5, subtypes A and C, tracheobronchial/gastric |
| Synonyms | 2210005L13Rik, AABR07006032.1, leB, LOC100132635, LOC101059911, LOC101927530, MGM, MUC5, mucin, mucin 5AC, oligomeric mucus/gel-forming, mucin 5, subtypes A and C, tracheobronchial/gastric, TBM |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Muc5ac often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycoprotein hormone beta chain homologues
- von Willebrand factor type C domain
- Trypsin Inhibitor like cysteine rich domain
- trypsin inhibitor-like cysteine rich domain
- Mucin-2 protein WxxW repeating region
- von Willebrand factor type D domain
- extracellular matrix structural constituent
- protein binding
- von Willebrand factor (vWF) type D domain
- C8 domain
Pathways
Biological processes and signaling networks where the Muc5ac gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- cholelithiasis
- airway inflammation
- postmenopausal osteoporosis
- osteoarthritis
- habitual abortion
- gallstone
- infection by parasite
role in cell
- accumulation
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi lumen
- extracellular vesicles
- Extracellular Space
- Plasma Membrane
- intercellular junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Muc5ac gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- extracellular matrix
- Golgi lumen
- plasma membrane
- mucus layer
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- extracellular matrix structural constituent