Pole4 Gene Summary [Mouse]
Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be involved in DNA-templated DNA replication. Predicted to be part of ATAC complex and epsilon DNA polymerase complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and integumental system. Orthologous to human POLE4 (DNA polymerase epsilon 4, accessory subunit). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Pole4 |
| Official Name | polymerase (DNA-directed), epsilon 4 (p12 subunit) [Source:MGI Symbol;Acc:MGI:1914229] |
| Ensembl ID | ENSMUSG00000030042 |
| Bio databases IDs | |
| Aliases | polymerase (DNA-directed), epsilon 4 (p12 subunit) |
| Synonyms | 2400007P05Rik, 5830430F06RIK, DNA polymerase epsilon 4, accessory subunit, DNA polymerase ε 4, accessory subunit, p12, polymerase (DNA-directed), epsilon 4 (p12 subunit), polymerase (DNA-directed), ε 4 (p12 subunit), YHHQ1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pole4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone fold domain (HFD) superfamily
- DNA-directed DNA polymerase
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Pole4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- diffuse large B-cell lymphoma
- cutaneous mastocytosis
- chronic lymphocytic leukemia
- lymphocytic leukemia
- intermediate-risk acute myeloid leukemia
- secondary progressive multiple sclerosis
- RUNX1-RUNX1T1 positive acute myeloid leukemia
- indolent systemic mastocytosis
- mantle cell lymphoma
phenotypes
- abnormal B cell differentiation
- abnormal DNA replication
- abnormal T cell differentiation
- abnormal cell cycle
- abnormal craniofacial morphology
- abnormal embryo development
- abnormal fourth ventricle morphology
- abnormal gait
- abnormal mesenteric lymph node morphology
- abnormal pelvic girdle bone morphology
- abnormal roof plate morphology
- abnormal spleen B cell follicle morphology
- abnormal thymus morphology
- absent thymus cortex
- anemia
- arrested B cell differentiation
- ataxia
- athymia
- belly spot
- caudal vertebral fusion
- chromosomal instability
- curly tail
- decreased B cell number
- decreased body length
- decreased body weight
- decreased brain weight
- decreased embryo size
- decreased embryo weight
- decreased fetal size
- decreased fetal weight
- decreased fibroblast proliferation
- decreased hematopoietic stem cell number
- decreased leukocyte cell number
- decreased litter size
- decreased lymphocyte cell number
- decreased male germ cell number
- decreased single-positive T cell number
- decreased spleen weight
- embryonic lethality during organogenesis incomplete penetrance
- impaired coordination
- increased T cell derived lymphoma incidence
- increased cellular sensitivity to hydroxyurea
- increased double-negative T cell number
- increased embryonic tissue cell apoptosis
- increased forebrain apoptosis
- increased granulocyte number
- increased hematopoietic stem cell number
- increased lymphoma incidence
- increased monocyte cell number
- induced chromosome breakage
- kinked tail
- lethality throughout fetal growth and development incomplete penetrance
- postnatal growth retardation
- prenatal growth retardation
- prominent forehead
- reduced cerebellar foliation
- reduced fertility
- short mandible
- short tibia
- small cerebellum
- small spleen
- thrombocytosis
role in cell
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pole4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA-dependent DNA replication
- DNA biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- epsilon DNA polymerase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- DNA-directed DNA polymerase activity
- protein binding
- protein heterodimerization activity