Pole4 Gene Summary [Mouse]
Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be involved in DNA-templated DNA replication. Predicted to be part of ATAC complex and epsilon DNA polymerase complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and integumental system. Orthologous to human POLE4 (DNA polymerase epsilon 4, accessory subunit). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Pole4 |
| Official Name | polymerase (DNA-directed), epsilon 4 (p12 subunit) [Source:MGI Symbol;Acc:MGI:1914229] |
| Ensembl ID | ENSMUSG00000030042 |
| Bio databases IDs | |
| Aliases | polymerase (DNA-directed), epsilon 4 (p12 subunit) |
| Synonyms | 2400007P05Rik, 5830430F06RIK, DNA polymerase epsilon 4, accessory subunit, DNA polymerase ε 4, accessory subunit, p12, polymerase (DNA-directed), epsilon 4 (p12 subunit), polymerase (DNA-directed), ε 4 (p12 subunit), YHHQ1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pole4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone fold domain (HFD) superfamily
- DNA-directed DNA polymerase
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Pole4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- diffuse large B-cell lymphoma
- cutaneous mastocytosis
- chronic lymphocytic leukemia
- lymphocytic leukemia
- intermediate-risk acute myeloid leukemia
- secondary progressive multiple sclerosis
- RUNX1-RUNX1T1 positive acute myeloid leukemia
- indolent systemic mastocytosis
- mantle cell lymphoma
role in cell
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pole4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA-dependent DNA replication
- DNA biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- epsilon DNA polymerase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- DNA-directed DNA polymerase activity
- protein binding
- protein heterodimerization activity