Nmi Gene Summary [Mouse]
Predicted to enable identical protein binding activity. Involved in positive regulation of inflammatory response; response to virus; and toll-like receptor 4 signaling pathway. Acts upstream of or within negative regulation of innate immune response; negative regulation of type I interferon production; and positive regulation of protein K48-linked ubiquitination. Located in extracellular space. Is expressed in genitourinary system; limb; and retina. Orthologous to human NMI (N-myc and STAT interactor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nmi |
| Official Name | N-myc (and STAT) interactor [Source:MGI Symbol;Acc:MGI:1928368] |
| Ensembl ID | ENSMUSG00000026946 |
| Bio databases IDs | |
| Aliases | N-myc (and STAT) interactor |
| Synonyms | N-myc (and STAT) interactor, N-myc and STAT interactor, N-MYC INTERACTOR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nmi often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- transcription regulator
- Nmi/IFP35 domain
- protein binding
- Interferon-induced 35 kDa protein (IFP 35) N-terminus
- identical protein binding
- Nmi/IFP 35 domain (NID)
Pathways
Biological processes and signaling networks where the Nmi gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multiple sclerosis
- COVID-19
- spinal cord demyelination
- insulitis
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- neonatal late-onset sepsis
- Hutchinson-Gilford progeria syndrome
- psoriasis
role in cell
- binding in
- expression in
- apoptosis
- proliferation
- activation
- interaction in
- replication in
- activation in
- cellular infiltration
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- cellular membrane
- Nucleus
- granules
- cytosol
- nuclear foci
- nucleoplasm
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nmi gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein K48-linked ubiquitination
- negative regulation of cell proliferation
- toll-like receptor 4 signaling pathway
- positive regulation of inflammatory response
- macrophage activation involved in immune response
- response to virus
- negative regulation of innate immune response
- JAK-STAT cascade
- positive regulation of innate immune response
- innate immune response
- negative regulation of interferon-alpha production
- negative regulation of interferon-beta production
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- cytoplasm
- membrane
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding