Mtrex Gene Summary [Mouse]
Predicted to enable ATP binding activity and RNA helicase activity. Predicted to be involved in DNA damage response; RNA catabolic process; and maturation of 5.8S rRNA. Predicted to be located in nucleoplasm. Predicted to be part of TRAMP complex; catalytic step 2 spliceosome; and nuclear exosome (RNase complex). Is expressed in medial ganglionic eminence. Orthologous to human MTREX (Mtr4 exosome RNA helicase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mtrex |
| Official Name | Mtr4 exosome RNA helicase [Source:MGI Symbol;Acc:MGI:1919448] |
| Ensembl ID | ENSMUSG00000016018 |
| Bio databases IDs | |
| Aliases | Mtr4 exosome RNA helicase |
| Synonyms | 2610528A15Rik, Dob1, fSAP118, KIAA0052, mKIAA0052, Mtr4, Mtr4 exosome RNA helicase, RGD1305984, SKIV2L2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mtrex often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- rRNA-processing arch domain
- DEAD/DEAH box helicase
- helicase superfamily c-terminal domain
- ATP binding
- enzyme
- DSHCT (NUC185) domain
- protein binding
- Helicase conserved C-terminal domain
- RNA helicase
- 6-pyruvoyl-tetrahydropterin synthase related domain (membrane protein)
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- catalytic step 2 spliceosome
- spliceosomes
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mtrex gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maturation of 5.8S rRNA
- snRNA catabolic process
- rRNA processing
- response to DNA damage stimulus
- nuclear mRNA splicing, via spliceosome
- RNA catabolic process
Cellular Component
Where in the cell the gene product is active
- nuclear exosome (RNase complex)
- nucleus
- catalytic step 2 spliceosome
- nuclear speck
- nucleolus
- TRAMP complex
- exosome (RNase complex)
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- RNA binding
- RNA helicase activity