Cnksr1 Gene Summary [Mouse]
Predicted to enable protein-macromolecule adaptor activity. Predicted to act upstream of or within Ras protein signal transduction and Rho protein signal transduction. Predicted to be located in cell cortex. Orthologous to human CNKSR1 (connector enhancer of kinase suppressor of Ras 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cnksr1 |
| Official Name | connector enhancer of kinase suppressor of Ras 1 [Source:MGI Symbol;Acc:MGI:2670958] |
| Ensembl ID | ENSMUSG00000028841 |
| Bio databases IDs | |
| Aliases | connector enhancer of kinase suppressor of Ras 1 |
| Synonyms | CNK, CNK1, connector enhancer of kinase suppressor of Ras 1, CONNECTOR ENHANCER of KSR-LIKE |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cnksr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SAM (Sterile alpha motif )
- SAM domain
- protein binding activity, bridging
- canonical PDZ domain
- protein binding
- Pleckstrin homology-like domain
- CRIC domain
- proline rich domain
- Connector enhancer of kinase suppressor of ras
- Sterile alpha motif
- SAM domain (Sterile alpha motif)
- PH domain
- pro domain
Pathways
Biological processes and signaling networks where the Cnksr1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- androgenic alopecia
- doxorubicin induced cardiotoxicity
- autosomal recessive nonsyndromic mental retardation
- breast ductal carcinoma in situ
- ductal in situ breast cancer
- Alzheimer disease
- breast carcinoma
role in cell
- growth
- generation in
- phosphorylation in
- apoptosis
- proliferation
- activation in
- cell focus formation
- proliferation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- cell cortex
- Plasma Membrane
- intercellular junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cnksr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane receptor protein tyrosine kinase signaling pathway
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- cell cortex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein binding, bridging