Arf3 Gene Summary [Mouse]
Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to act upstream of or within protein transport. Located in Golgi apparatus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ARF3 (ARF GTPase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arf3 |
| Official Name | ADP-ribosylation factor 3 [Source:MGI Symbol;Acc:MGI:99432] |
| Ensembl ID | ENSMUSG00000051853 |
| Bio databases IDs | |
| Aliases | ADP-ribosylation factor 3 |
| Synonyms | 5430400P17Rik, Ac1-253, AI854770, ARF GTPase 3, LOC100912045 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arf3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- GTP binding domain-switch II region
- effector loop
- ADP-ribosylation factor family
- myristoylation sequence
- GTPase
- enzyme
- protein binding
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Arf3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Golgi Apparatus
- cytosol
- Golgi membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arf3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
- retrograde vesicle-mediated transport, Golgi to ER
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- cytoplasm
- Golgi membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity