Nlk Gene Summary [Mouse]
Enables several functions, including ATP binding activity; SH2 domain binding activity; and magnesium ion binding activity. Involved in several processes, including peptidyl-threonine phosphorylation; regulation of DNA-templated transcription; and regulation of signal transduction. Acts upstream of or within protein autophosphorylation. Located in nucleus. Is expressed in several structures, including early embryo; genitourinary system; nervous system; neural retina; and respiratory system. Orthologous to human NLK (nemo like kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nlk |
| Official Name | nemo like kinase [Source:MGI Symbol;Acc:MGI:1201387] |
| Ensembl ID | ENSMUSG00000017376 |
| Bio databases IDs | |
| Aliases | nemo like kinase |
| Synonyms | LOC100044468, LOC120095148, nemo like kinase, RGD1561602 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nlk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- protein serine/threonine kinase
- protein kinase
- SH2-domain binding
- ATP binding
- transcription factor binding
- protein binding
- magnesium ion binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- MAP kinase
Pathways
Biological processes and signaling networks where the Nlk gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- abdominal cancer
- epithelial cancer
- epithelial neoplasia
- liver cancer
- liver neoplasia
- digestive system cancer
- major depression
- microgliosis
- silicosis
role in cell
- phosphorylation in
- survival
- binding in
- quantity
- formation
- proliferation
- differentiation
- number
- response by
- Clathrin mediated endocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- membrane fraction
- Cytoplasm
- cytosol
- nucleoplasm
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nlk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- cellular response to osmotic stress
- transforming growth factor beta receptor signaling pathway
- Wnt receptor signaling pathway, calcium modulating pathway
- regulation of transcription, DNA-dependent
- negative regulation of Wnt receptor signaling pathway
- protein phosphorylation
- protein stabilization
- intracellular signal transduction
- peptidyl-threonine phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- protein binding
- ubiquitin protein ligase binding
- MAP kinase activity
- protein kinase activity
- protein serine/threonine kinase activity
- SH2 domain binding