Tab2 Gene Summary [Mouse]
Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity; molecular adaptor activity; and zinc ion binding activity. Predicted to be involved in several processes, including non-canonical NF-kappaB signal transduction; positive regulation of canonical NF-kappaB signal transduction; and response to bacterium. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in cardiomyopathy; congenital heart disease; and ovary epithelial cancer. Orthologous to human TAB2 (TGF-beta activated kinase 1 (MAP3K7) binding protein 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tab2 |
| Official Name | TGF-beta activated kinase 1/MAP3K7 binding protein 2 [Source:MGI Symbol;Acc:MGI:1915902] |
| Ensembl ID | ENSMUSG00000015755 |
| Bio databases IDs | |
| Aliases | TGF-beta activated kinase 1/MAP3K7 binding protein 2 |
| Synonyms | 1110030N06Rik, A530078N03Rik, CHTD2, LOC101928709, MAP3K7IP2, mKIAA0733, RP1 111D63, TGF-beta activated kinase 1 (MAP3K7) binding protein 2, TGF-beta activated kinase 1/MAP3K7 binding protein 2, TGF-β activated kinase 1 (MAP3K7) binding protein 2, TGF-β activated kinase 1/MAP3K7 binding protein 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tab2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- NZF domain
- Zn-finger in Ran binding protein and others
- zinc ion binding
- ubiquitin binding domain
- nuclear protein localization 4 zinc finger domain
- coiled-coil domain
- protein binding
- zinc finger domain
- zDHHC ankyrin repeat binding domain
- HR1
Pathways
Biological processes and signaling networks where the Tab2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- bleeding
- hereditary disorder
- breast carcinoma
- dilated cardiomyopathy
- nonsyndromic congenital heart disease type 2
- dementia
- coronary artery disease
- primary dilated cardiomyopathy
- Dupuytren contracture
role in cell
- apoptosis
- expression in
- necrosis
- phosphorylation in
- migration
- activation in
- proliferation
- activity
- binding in
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- cellular membrane
- Nucleus
- Plasma Membrane
- cytosol
- endosomal membrane
- nucleoplasm
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tab2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- inflammatory response
- positive regulation of protein kinase activity
- negative regulation of autophagy
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- NIK/NF-kappaB cascade
- response to lipopolysaccharide
- defense response to bacterium
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- endosome membrane
- plasma membrane
- lysosomal membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- ubiquitin binding
- K63-linked polyubiquitin binding
- binding, bridging