Wsb1 Gene Summary [Mouse]
Enables ubiquitin protein ligase activity. Involved in protein K27-linked ubiquitination. Acts upstream of or within protein aggregate center assembly. Located in cytoplasm. Is expressed in nervous system and neural retina. Orthologous to human WSB1 (WD repeat and SOCS box containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wsb1 |
| Official Name | WD repeat and SOCS box-containing 1 [Source:MGI Symbol;Acc:MGI:1926139] |
| Ensembl ID | ENSMUSG00000017677 |
| Bio databases IDs | |
| Aliases | WD repeat and SOCS box-containing 1 |
| Synonyms | 1110056B13RIK, 2700038M07Rik, Socs box 1, SWIP1, WD repeat and SOCS box-containing 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wsb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SOCS box
- WD40 repeats
- ubiquitin protein ligase activity
- WD domain, G-beta repeat
- SOCS
- WD40
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- breast cancer
- septic shock
- metastasis
- metastasis-free survival
role in cell
- apoptosis
- expression in
- invasion by
- proliferation
- G1 phase
- ubiquitination in
- proliferation in
- stabilization in
- degradation in
- destabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wsb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyubiquitination
- protein K27-linked ubiquitination
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding