Usp10 Gene Summary [Mouse]
Predicted to enable several functions, including cysteine-type peptidase activity; p53 binding activity; and transmembrane transporter binding activity. Predicted to be involved in several processes, including DNA damage response, signal transduction by p53 class mediator; monoubiquitinated protein deubiquitination; and negative regulation of canonical NF-kappaB signal transduction. Predicted to be located in cytoplasm; intermediate filament cytoskeleton; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytosolic ribosome; early endosome; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human USP10 (ubiquitin specific peptidase 10). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Usp10 |
| Official Name | ubiquitin specific peptidase 10 [Source:MGI Symbol;Acc:MGI:894652] |
| Ensembl ID | ENSMUSG00000031826 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 10 |
| Synonyms | 2610014N07RIK, mKIAA0190, Similar to ubiquitin C-terminal hydrolase-related polypeptide, Ubiquitin carboxyl-terminal hydrolase 10, ubiquitin specific peptidase 10, UBPO, UCHRP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Usp10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine endopeptidase
- peptidase
- Ubiquitin carboxyl-terminal hydrolase
- ion channel binding
- ubiquitin-specific protease
- p53 binding
- protein binding
- Peptidase_C19
Pathways
Biological processes and signaling networks where the Usp10 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- organismal death
- ocular sarcoidosis
- osteosarcoma
- osteosarcomagenesis
- breast cancer
- type I enteropathy-associated T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
role in cell
- expression in
- phosphorylation in
- proliferation
- production in
- migration
- activation in
- growth
- invasiveness
- apoptosis
- G1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intermediate filament cytoskeleton
- ribosome
- Nucleus
- cytosol
- nucleoplasm
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Usp10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- monoubiquitinated protein deubiquitination
- rescue of stalled ribosome
- autophagy
- proteolysis
- regulation of autophagy
- cellular response to interleukin-1
- DNA damage response, signal transduction by p53 class mediator
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- response to DNA damage stimulus
- translesion synthesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- early endosome
- cytosolic ribosome
- intermediate filament cytoskeleton
- cytoplasm
- cytosol
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- p53 binding
- protein binding
- RNA binding
- cysteine-type endopeptidase activity
- ion channel binding