Cadps2 Gene Summary [Mouse]
Predicted to enable lipid binding activity and metal ion binding activity. Involved in synaptic vesicle priming. Acts upstream of or within cellular response to starvation; hematopoietic stem cell homeostasis; and positive regulation of exocytosis. Located in cytoplasmic vesicle; postsynaptic membrane; and presynaptic membrane. Is active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and presynapse. Is expressed in several structures, including brain; genitourinary system; sensory organ; skeleton; and spinal cord. Used to study autism spectrum disorder. Orthologous to human CADPS2 (calcium dependent secretion activator 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cadps2 |
| Official Name | Ca2+-dependent activator protein for secretion 2 [Source:MGI Symbol;Acc:MGI:2443963] |
| Ensembl ID | ENSMUSG00000017978 |
| Bio databases IDs | |
| Aliases | Ca2+-dependent activator protein for secretion 2 |
| Synonyms | A230044C21Rik, Ca2+-dependent activator protein for secretion 2, calcium dependent secretion activator 2, CAPS2, Cpd2, RGD1559440 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cadps2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PH domain
- protein binding
- Pleckstrin homology-like domain
- Protein kinase C conserved region 2 (CalB)
- MUN domain
- C2 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- Alzheimer disease
- schizophrenia
- cardiovascular disorder
- osteoarthritis
- hyperactive behavior
- metabolic syndrome X
- autism
role in cell
- migration
- cell death
- quantity
- abnormal morphology
- development
- number
- function
- release
- exocytosis by
- specification
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic plasma membrane fractions
- vesicle membrane fractions
- glutaminergic synapse
- intracellular membrane-bounded organelle
- Cytoplasm
- presynaptic regions
- cilia
- cellular membrane
- basal bodies
- centrosome
- presynaptic membrane
- postsynaptic membrane
- nucleoplasm
- cytoplasmic vesicles
- axons
- dendrites
- excitatory synapses
- synaptic vesicle fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cadps2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transport
- synaptic vesicle exocytosis
- exocytosis
- positive regulation of exocytosis
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- intracellular membrane-bounded organelle
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- lipid binding